Expression of Interleukin-11 and Interleukin-11 receptor α in human colorectal adenocarcinoma; Immunohistochemical analyses and correlation with clinicopathological factors

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چکیده

منابع مشابه

Expression of interleukin (IL)-11 and IL-11 receptor in human colorectal adenocarcinoma: IL-11 up-regulation of the invasive and proliferative activity of human colorectal carcinoma cells.

Previous investigations have shown that interleukin (IL)-11/IL-11 receptor alpha-chain (IL-11Ralpha), a member of the PI3K, MAPK and JAK-STAT activating family of cytokines/receptors, correlates with the regulation of tumor progression. In this study, we established the IL-11/IL-11Ralpha expression profile in human colorectal adenocarcinoma (CRC) and clarified its signaling pathway and role in ...

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Signal transduction of interleukin-11 and interleukin-6 α-receptors

The cytokines Interleukin (IL)-11 and IL-6 are important mediators that regulate differentiation and proliferation of immune cells. Both cytokines bind to unique non-signaling α-receptors (IL-11R and IL-6R, respectively), and the resulting cytokine/cytokine receptor complexes recruit a homodimer of the signal-transducing β-receptor glycoprotein (gp)130. Gp130 is expressed ubiquitously, whereas ...

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Cytokeratin7 expression in gastric and colorectal adenocarcinoma: Correlation with prognostic factors

 Background: Gastric and colorectal adenocarcinoma are the second and the fifth most common cancers in Iran, respectively. Expression of cytokeratin 7 (CK7) is established in most malignancies including gastric and colorectal adenocarcinoma. Demonstration of Ck7 could be related to prognostic factors and help to the better management of the patients. The objective of our study was to evalu...

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Epidermal Growth Factor Receptor Expression in Oral Squamous Cell Carcinoma by Immunohistochemical Technique and its Correlation with Clinicopathological Features

Background:Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity. Despite some improvements in treatment, the survival rate is still very low, mainly due to the possible development of secondary malignancy or metastasis. Clinical and pathological features as well as molecular biomarkers might predict the recurrence. In recent years, many studies ...

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Expression and function of interleukin-11 and its receptor alpha in the human endometrium.

The interleukin-11 (IL-11) receptor alpha has an important function in decidualization of mouse endometrial stroma but the function of IL-11 and its receptor in the human endometrium remains unknown. The mRNA for IL-11 and its receptor alpha in human endometrial tissue samples were analysed by semi-quantitative RT-PCR and RNase protection assays respectively. The proteins were detected in froze...

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ژورنال

عنوان ژورنال: World Journal of Gastroenterology

سال: 2006

ISSN: 1007-9327

DOI: 10.3748/wjg.v12.i2.317